Molecular Formula | C24H19F2NO3 |
Molar Mass | 407.41 |
Density | 1.325 |
Melting Point | >57°C (dec.) |
Boling Point | 656.1±55.0 °C(Predicted) |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | White to Off-White |
pKa | 9.72±0.30(Predicted) |
Storage Condition | 2-8°C |
purpose | This product is the I-phase metabolite of ezetimibe (ETS 75000). |
biological activity | Ezetimibe ketone (EZM-K) is a phase I metabolite of Ezetimibe. Ezetimibe is an NPC1L1 inhibitor, a potent activator of Nrf2, and Ezetimibe is also a potent inhibitor of cholesterol absorption. |
Target | NPC1L1, Nrf2 |